Professor Matthias Marti’s research efforts are focused on basic and translational aspects of malaria transmission stages. Current efforts for malaria elimination and eventual eradication have generated renewed interest in the biology of malaria transmission and transmission blocking interventions. The Marti laboratory developed the first high throughput screen targeting malaria transmission stages. More recent work focuses on development of tools for the detection and quantification of malaria transmission stages during human infection. Professor Marti is studying the formation and development of these stages in human red blood cells using an in vitro model and during human infection. These studies have revealed a unique sequestration site in the human bone marrow. Professor Marti is involved in several field collaborations in Malawi and Nigeria.
Professor Marti earned his master’s degree in Medical Parasitology at the Swiss Public Tropical and Public Health Institute on the subject of development of a drug screen for the intestinal parasite, Giardia lamblia. After training in molecular parasitology at the University of Texas at El Paso he earned a Doctor of Philosophy on the mechanisms of protein secretion in Giardia at the University of Zurich. He completed postdoctoral research at the Walter and Eliza Hall Institute in Melbourne, Australia, where he identified a novel protein secretion mechanism in human malaria parasites.